Separation technologies, such as liquid chromatography (LC) coupled with mass spectrometry (MS), are the principal analysis techniques for identifying and quantifying compounds. The ever-increasing demands of modern analysts, and novel application workflows, have led to the evolution of these instruments. When working with complex matrices, triple quadrupole (QqQ) mass spectrometers have established popularity in quantifying analytes at very low detection limits, with specificity and selectivity. Similarly, high-resolution accurate-mass (HRAM) spectrometers are also known for their outstanding selectivity, specificity, and sensitivity when working with challenging matrices